Musculoskeletal Regenerative Engineering Laboratory

The Musculoskeletal Regenerative Engineering Lab focuses on understanding the fundamental mechanisms by which biomaterial interfaces alter the proliferation, migration, and differentiation of mesenchymal stem cells to guide the design of biomaterial scaffolds and facilitate the generation or regeneration of musculoskeletal tissues.

Current research in the lab involves the investigation of the interface between osteoprogenitor cells and synthetic nanofibers. Such as: the application of systems biology to elucidate the alterations in the interactome of an osteoprogenitor on nanofiber substrates as the cell population progresses from adhesion, to migration and proliferation, and finally differentiation; and also the utilization of polymer chemistry to modulate the diameter of synthetic nanofibers across several orders of magnitude and evaluate the subsequent alterations and interactions of focal adhesion proteins.