MINIBio

Refereed Journal Articles

Representative Publications

• Rapid isolation of extracellular vesicles via lipid nanoprobes, Y. Wan, G. Cheng, X. Liu, S.-J. Hao, M. Nisic, C.-D. Zhu, Y.-Q.Xia, W.-Q. Li, Z.-G. Wang, W.-L. Zhang, S. J. Rice, A. Sebastian, I. Albert, C. P. Belani, S.-Y. Zheng, Nature Biomedical Engineering, 1, 0058, 2017. (Feature as front cover story) [Link] [Behind the Paper] [PSU News Release]
• Tunable and label-free virus enrichment for ultrasensitive virus detection using carbon nanotube arrays, Y.-T. Yeh, Y. Tang, A. Sebastian, A. Dasgupta, N. Perea-Lopez, I. Albert, H. Lu, M. Terrones, and S.-Y. Zheng, Science Advances, 2, e1601026, 2016. [Link] [pdf] [video] [PSU News Release] [NIH Director's blog]
• Self-assembly of extracellular vesicle-like metal–organic framework nanoparticles for protection and intracellular delivery of biofunctional proteins, G. Cheng, W. Li, L. Ha, X. Han, S. Hao, Y. Wan, Z. Wang, F. Dong, X. Zou, Y. Mao, & S.-Y. Zheng, Journal of the American Chemical Society, 140, 7282-7291, 2018. (Feature as supplementary cover story) [Link] [PSU News Release]
• Flexible micro spring array device for high throughput enrichment of viable circulating tumor cells, R. A. Harouaka, M.-D. Zhou, Y.-T. Yeh, W. J. Khan, A. Das, X. Liu, C. C. Christ, D. T. Dicker, T. S. Baney, J. T. Kaifi, C. P. Belani, C. I. Truica, W. S. El-Deiry, J. P. Allerton, and S.-Y. Zheng, Clinical Chemistry, vol. 60, pp. 323-333, 2014. [pdf]

2018

• Self-assembly of extracellular vesicle-like metal–organic framework nanoparticles for protection and intracellular delivery of biofunctional proteins, G. Cheng, W. Li, L. Ha, X. Han, S. Hao, Y. Wan, Z. Wang, F. Dong, X. Zou, Y. Mao, & S.-Y. Zheng, Journal of the American Chemical Society, 140, 7282-7291, 2018. (Feature as supplementary cover story) [Link] [PSU News Release]
• Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug, W.-Q. Li, Z. Wang, S. Hao, L. Sun, M. Nisic, G. Cheng, C. Zhu, Y. Wan, L. Ha, L. & S.-Y. Zheng, Nanoscale, 10, 3744-3752, 2018. [Link]
• Light-emitting transition metal dichalcogenide monolayers under cellular digestion, Y.-T. Yeh, Y. Tang, Z. Lin, K. Fujisawa, Y. Lei, Y. Zhou, C. Rotella, A. L. Elias, S.-Y. Zheng, Y. Mao, Z. Liu, H. Lu, & M. Terrones, Advanced Materials, 30, 1703321, 2018. [Link]
• A spontaneous 3D bone-on-a-chip for bone metastasis study of breast cancer cells, S. Hao, L. Ha, G. Cheng, Y. Wan, Y. Xia, D. M. Sosnoski, A. M. Mastro, and S.-Y. Zheng, Small, 14, 1702787, 2018. [Link] [Physicsworld]
• Pre-occupation of empty carriers decreases endo/lysosome escape and reduces the protein delivery efficiency of mesoporous silica nanoparticles, W. Li, L. Sun, Y. Xia, S.-J. Hao, G. Cheng, Z. Wang, Y. Wan, C. Zhu, H. He, and S.-Y. Zheng, ACS Applied Materials & Interfaces, 10, 5340-5347, 2018. [Link]
• Size-based separation methods of circulating tumor cells, S.-J. Hao, Y. Wan, Y.-Q. Xia, X. Zou, and S.-Y. Zheng, Advanced Drug Delivery Reviews, 25, 3-20, 2018. [Link]
• In situ caging of biomolecules in graphene hybrids for light modulated bioactivity, G. Cheng, X.-H. Han, S.-J. Hao, M. Nisic, and S.-Y. Zheng, ACS Applied Materials & Interfaces, 10, 3361-3371, 2018. [Link]
• Aptamer conjugated extracellular nanovesicles for in vivo targeted drug delivery, Y. Wan, L. Wang, C. Zhu, Q. Zheng, G. Wang, J. Tong, Y. Fang, Y.-Q. Xia, G. Cheng, X. He, and S.-Y. Zheng, Cancer Research, 78, 798-808, 2018. [Link]

2017

• Chopper-Modulated gas chromatography electroantennography enabled using high-temperature MEMS flow control device, M.-D. Zhou, M. Akbar, A. J. Myrick, Y. Xia, W. J. Khan, X. Gao, T. C. Baker and S.-Y. Zheng, Microsystems & Nanoengineerin, Nature Publishing Group, 3, 17062, 2017. [Link] [pdf]
• Rapid isolation of extracellular vesicles via lipid nanoprobes, Y. Wan, G. Cheng, X. Liu, S.-J. Hao, M. Nisic, C.-D. Zhu, Y.-Q.Xia, W.-Q. Li, Z.-G. Wang, W.-L. Zhang, S. J. Rice, A. Sebastian, I. Albert, C. P. Belani, S.-Y. Zheng, Nature Biomedical Engineering, 1, 0058, 2017. (Feature as front cover story) [Link] [Behind the Paper] [PSU News Release]
• Self-assembly of smart multifunctional hybrid compartments with programmable bioactivity, G. Cheng, S.-J.Hao, Y. Wan, D.-Y.Shan, J. Yang, S.-Y. Zheng, Chemistry of Materials, 29 (5), 2081-2089, 2017. [Link]
• Evaluating a novel dimensional reduction approach for mechanical fractionation of cells using a tandem flexible micro spring array (tFMSA), Y. T. Yeh, R. A. Harouaka, S. -Y. Zheng, Lab on a Chip, 17 (4), 691-701, 2017. [Link]
• Label-free virus capture and release by a microfluidic device integrated with porous silicon nanowire forest, Y. Xia, Y. Tang, X. Yu, Y. Wan, Y. Chen, H. Lu, S.-Y. Zheng, Small, 13 (6), 1603135, 2017. (Feature as inside front cover story) [Link]
• Mitochondria-Targeting Polydopamine Nanoparticles to Deliver Doxorubicin for Overcoming Drug Resistance, W. Li, Z. Wang, S.-J. Hao, H.He, Y. Wan,C. Zhu, L. Sun, G. Cheng & S. -Y. Zheng, ACS Applied Materials & Interfaces, 9, 16793–16802, 2017.) [Link]
• A Nanostructured Microfluidic Immunoassay Platform for Highly Sensitive Infectious Pathogen Detection, X. Yu, Y. Xia, Y. Tang, W.-L. Zhang, Y.-T. Yeh, H. Lu & S.-Y. Zheng, Small, 13, 1700425, 2017. (Feature as inside front cover story) [Link] [Nanowerk]

2016

• Tunable and label-free virus enrichment for ultrasensitive virus detection using carbon nanotube arrays, Y.-T. Yeh, Y. Tang, A. Sebastian, A. Dasgupta, N. Perea-Lopez, I. Albert, H. Lu, M. Terrones, and S.-Y. Zheng, Science Advances, 2, e1601026, 2016. [Link] [pdf] [video] [PSU News Release] [NIH Director's blog]
• G-Fresnel smartphone spectrometer, C. Zhang, G. Cheng, P. Edwards, M.-D. Zhou, S.-Y. Zheng, and Z. Liu, Lab on a Chip, 16, 246-250, 2016. [Link]
• Synthesis and characterization of anti-bacterial and anti-fungal citrate-based mussel-inspired bioadhesives, J. Guo, W. Wang, J. Hu, D. Xie, E. Gerhard, M. Nisic, D. Shan, G. Qian, S.-Y. Zheng, and J. Yang, Biomaterials, 85, 204-217, 2016. [Link]
• A multiplexed marker-based algorithm for diagnosis of carcinoma of unknown primary using circulating tumor cells, E. M. Matthew, L. Zhou, Z. Yang, D. T. Dicker, S. L. Holder, B. Lim, R. Harouaka, S.-Y. Zheng, J. J. Drabick, N. E. Lamparella, C. I. Truica, and W. S. El-Deiry, Oncotarget, 7, 3662-3676, 2016. [Link]
• Graphene-Templated Synthesis of Magnetic Metal Organic Framework Nanocomposites for Selective Enrichment of Biomolecules, G. Cheng, Z. G. Wang, S. Denagamage, and S.-Y. Zheng, ACS Appl Mater Interfaces, 8, 10234-10242, 2016. [Link]

2015

• Circulating tumor cell isolation during resection of colorectal cancer lung and liver metastases: a prospective trial with different detection techniques, J. T. Kaifi, M. Kunkel, Miriam, A. Das, R. A. Harouaka, D. T. Dicker, G. Li, J. Zhu, G. A. Clawson, Z. Yang, M. F. Reed, N. J. Gusani, E. T. Kimchi, K. F. Staveley-O'Carroll, S.-Y. Zheng, and W. S. El-Deiry, Cancer Biology & Therapy, 16, 699-708, 2015. [Link]
• On-Demand One-Step Synthesis of Monodisperse Functional Polymeric Microspheres with Droplet Microfluidics, X. Yu, G. Cheng, M.-D. Zhou & S.-Y. Zheng, Langmuir, 31, 3982-3992, 2015. [Link]
• A combinatory strategy for detection of live CTCs using microfiltration and a new telomerase-selective adenovirus, Y. Ma†, S. Hao†, S. Wang, Y. Zhao, B. Lim, M. Lei, D. J. Spector, W. S. El-Deiry, S.-Y. Zheng and J. Zhu, Molecular Cancer Therapeutics, 14, 835-843, 2015. (†Authors with equal contribution) [Link]
• Nanostructured microfluidic digestion system for rapid high-performance proteolysis, G. Cheng, S.-J. Hao, X. Yu and S.-Y. Zheng, Lab on Chip, 15, 650-654, doi:10.1039/C4LC01165A, 2015. [Link]
• Highly sensitive DNA detection using cascade amplification strategy based on hybridization chain reaction and enzyme-induced metallization, X. Yu, Z.-L. Zhang and S.-Y. Zheng, Biosens. Bioelectron., 66, 520-526, 2015. [Link]

2014

• Separable bilayer microfiltration device for viable label-free enrichment of circulating tumour cells, M.-D. Zhou†, S. Hao†, A. J. Williams†, R. A. Harouaka, B. Schrand, S. Rawal, Z. Ao, R. Brennaman, E. Gilboa, B. Lu, S. Wang, J. Zhu, R. Datar, R. Cote, Y.-C. Tai*, and S.-Y. Zheng*, Scientific Reports, 4: 7392, 1-10, doi:10.1038/srep07392, 2014. (†Authors with equal contribution) [pdf]
• Construction of a high-performance magnetic enzyme nanosystem for rapid tryptic digestion, G. Cheng and S.-Y. Zheng, Scientific Reports, 4: 6947, 1-10, doi:10.1038/srep06947, 2014. [pdf]
• Facile synthesis of magnetic mesoporous hollow carbon microspheres for rapid capture of low-concentration peptides, G. Cheng, M.-D. Zhou, S.-Y. Zheng, ACS Applied Materials & Interfaces, 6, 12719-12728, 2014. [Link]
• Point-of-care microdevices for blood plasma analysis in viral infectious diseases, Y.-T. Yeh, M. Nisic, X. Yu, Y. Xia, S.-Y. Zheng, Annals of Biomedical Engineering, 42, 2333-2343, 2014. [Link]
• Preparation of magnetic graphene composites with hierarchical structure for selective capture of phosphopeptides, G. Cheng, X. Yu, M. Zhou, and S.-Y. Zheng, J. Mater. Chem. B, 2, 4711-4719, 2014. [Link]
• Flexible micro spring array device for high throughput enrichment of viable circulating tumor cells, R. A. Harouaka, M.-D. Zhou, Y.-T. Yeh, W. J. Khan, A. Das, X. Liu, C. C. Christ, D. T. Dicker, T. S. Baney, J. T. Kaifi, C. P. Belani, C. I. Truica, W. S. El-Deiry, J. P. Allerton, and S.-Y. Zheng, Clinical Chemistry, vol. 60, pp. 323-333, 2014. [pdf]
• Circulating tumor cells: advances in isolation and analysis, and challenges for clinical applications, R. A. Harouaka, Z. Kang, S.-Y. Zheng, L. Cao, Pharmacology and Therapeutics, vol.141, pp. 209-221, 2014. [Link]

2013

• Circulating tumor cell enrichment based on physical properties, R. A. Harouaka, M. Nisic, S.-Y. Zheng, Journal of Laboratory Automation, vol. 18, pp. 455-468, 2013. (Featured as cover image) [Link]
• Predicting therapy response in live tumor cells isolated with the flexible micro spring array device. Gallant, J.-N.; Matthew, E. M.; Cheng, H.; Harouaka, R.; Lamparella, N. E.; Kunkel, M.; Yang, Z.; Harvey, H. A.; Cream, L. V.; Kumar, S. M.; Robertson, G. P.; Zheng, S.; Drabick, J. J.; Truica, C. I.; El-Deiry, W. S., Cell Cycle, vol.12, pp. 2132-2143, 2013. [pdf]

2012

• Microfluidic device and system for point-of-care blood coagulation measurement based on electrical impedance sensing, B. Ramaswamy, Y. T. Yeh, and S. Y. Zheng, Sensors and Actuators B: Chemical, vol. 14(1), pp. 235-245, 2012. [Link]
• An Implantable Fabry–Pérot Pressure Sensor Fabricated on Left Ventricular Assist Device for Heart Failure, M. D. Zhou, C. Yang, Z. Liu, J. P. Cysyk, and S. Y. Zheng, Biomedical Microdevices, vol.14, pp. 235-245, 2012. [Link]
• Z-microscopy for parallel axial imaging with micro mirror array, C. Yang, K. Shi, M. Zhou, S. Zheng, S. Yin, and Z. Liu, Applied Physics Letters, vol. 101, pp. 231111-5, 2012. [Link]
• Circulating tumor cells in melanoma patients, G. A. Clawson, E. Kimchi, S. D. Patrick, P. Xin, R. Harouaka, S. Zheng, A. Berg, T. Schell, K. F. Staveley-O’Carroll, R. J. Neves, P. J. Mosca, D. Thiboutot, PLoS ONE, vol. 7, p. e41052, 2012. [pdf]

2011

• 3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood, S. Zheng, H. K. Lin, B. Lu, A. Williams, R. H. Datar, R. J. Cote RJ, Y. –C. Tai, Biomedical Microdevices, vol.13, pp. 203-213, 2011. [Link]
• Disseminated and circulating tumor cells: role in effective patient management, H. Lin, M. Balic, S. Zheng, R. Datar, R.J. Cote, Critical Reviews in Oncology/Hematology, vol. 77(1), pp.1-11, 2011. [pdf]

2010

• Portable filter-based microdevice for detection and characterization of circulating tumor cells, H. K. Lin†, S. Zheng†, A. J. Williams, M. Balic, S. Groshen, H. I. Scher, M. Fleisher, W. Stadler, R. H. Datar, Y.-C. Tai, R. J. Cote, Clinical Cancer Research, vol 16, pp. 5011-5018, 2010.  (†Authors with equal contribution) [pdf]
• The autofluorescence study of parylene materials for mTAS applications, B. Lv, S. Zheng, B. Q. Quach and Y. -C. Tai, Lab on Chip, vol. 10(14), pp. 1826-34, 2010. [Link]

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Patents

• S.-Y. Zheng, G. Cheng, Nanoparticle for protein delivery, U.S. Provisional Patent Application No. 62/676,341, 2018.
• S.-Y. Zheng, Y. Wan, G. Cheng, Lipid nanoprobe for extracellular isolation, U.S. Provisional Patent 62/430,161, 2016.
• S.-Y. Zheng, M. Terrones, Y.-T. Yeh, Y. Tang, H. Lu, N. P. Lopez, Y. Xia. A size tunable enrichment platform for capturing nano particles in a fluid, U.S. Provisional Patent Application No. 62/193,876, 2015.
• S.-Y. Zheng, M.-D. Zhou, A. Myrick, Flow-Control Device for Gas Chromatograph, U.S. Patent Application No. 61/997,641, 2015.
• Z. Liu, C. Yang, K. Shi, M. Zhou, S.-Y. Zheng, S. Yin, Z-microscopy, US patent application 14/093,188, 2013.
• S.-Y. Zheng, R. A. Harouaka, M.-D. Zhou, Y.-T. Yeh, Flexible filter device for capturing of particles or cells in a fluid, US patent application 2013/0180909 A1 and PCT (International) Patent Application PCT/US2013/021933, 2013.
• S. Zheng, R. Cote, H. Lin, B. Lu, Y.-C. Tai, Method and apparatus for microfiltration to perform cell separation, US patent 8,815,092, 2014.
• Y.-C. Tai, S. Zheng, and H. Kasdan, Streamline-based microfluidic device, US patent 8,354,075, 2013.
• S. Zheng, R. J. Cote, H. Lin, B. Lu, and Y. C. Tai, Method and apparatus for microfiltration to perform cell separation, US patent 8,114,289, 2012.
• Y. C. Tai, S. Zheng, J. C.-H. Lin, and H. Kasdan, Fluorescent labeling, sensing and differentiation of leukocytes from undiluted whole blood samples, US patent 9,029,158 B2, 2015; 9,234,884 B2, 2016; 9,535,059 B2, 2017; 9,757,729 B2, 2017.
• Y.-C. Tai, C.-Y. Shih, W. Li, and S. Zheng, Resonance-Induced sensitivity enhancement method for conductivity sensors, US patent 7,629,797, 2007.
• Y. C. Tai, S. Zheng, H. Lin, R. Datar, and R. J. Cote, Uses of parylene membrane filters, US patent 7,846,743, 2010.
• Y. C. Tai, S. Zheng, H. Lin, R. Datar, and R. J. Cote, Membrane filter for capturing circulating tumor cells, US patent 7,846,393, 2010.
• Y. C. Tai, S. Miserendino, Q. He, and S. Zheng, Modular microfluidic packaging syste, US patent application 11/192,434, 2006.
• Y. C. Tai, C. Y. Shih, and S. Zheng, Method and system for processing nanoparticles using a self-assembly mechanism to form combined species, US patent application 10/985,841, 2006.

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Publications Before 2009 Link