Cell Signaling and Cancer
Cell signaling and protein dynamics focuses on intercellular and intracellular communications between proteins and cells at both cellular and molecular levels. Researchers integrate both in vitro and in vivo biological experiments with cell, protein and fluid transport dynamics in the areas of cancer metastasis, tumor microenvironment and extravasation, leukocyte adhesion, mechanobiology, energy metabolism, and system network biology. At the cellular level, investigators develop cell mechanics and biofluid transport models within the microcirculation. At the molecular level, we construct models in reaction kinetics, protein diffusion and convection, and signaling pathway network. Interdisciplinary collaborations extend biomedical engineering research within the College of Engineering to College of Medicine, College of Science, Huck Institutes for Life Sciences, and the Penn State Cancer Institute.