Journal Articles
- Chuan Liu, Scott M Leighow, Kyle McIlroy, Mengrou Lu, Kady A Dennis, Kerry Abello, Donovan J Brown, Connor J Moore, Anushka Shah, Haider Inam, Victor Rivera and Justin Pritchard, 2023, "Excessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing", Cell Reports Medicine, 4, (10), pp. 17
- Atip Lawanprasert, Janna Sloand, Mariangely González Vargas, Harminder Singh, Tomer Eldor, Michael Miller, Sopida Pimcharoen, Jian Wang, Scott Leighow, Justin Pritchard, Nikolay V Dokholyan and Scott H Medina, 2023, "Deciphering the Mechanistic Basis for Perfluoroalkyl-Protein Interactions", ChemBioChem, 24, (13)
- Justin Pritchard, Michael J Lee and Shelly R Peyton, 2022, "Materials-driven approaches to understand extrinsic drug resistance in cancer", Soft Matter, 18, (18)
- Thu Nguyen-Anh Tran, Nathan B Wikle, Fuhan Yang, Haider Inam*, Scott Leighow*, Bethany Gentilesco, Phillip Chan, Emmy Albert, Emily R Strong, Justin Pritchard, William P Hanage, Ephraim M Hanks, Forest M Crawford and Maciej J Boni, 2022, "SARS-CoV-2 Attack Rate and Population Immunity in Southern New England, March 2020 to May 2021", JAMA Network Open, 5, (5)
- Boyang Zhao*, Yiyun Rao*, Scott Leighow*, Edward P O'brien and Justin Pritchard, 2022, "A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments", Nature Communications, 13, (1)
- Suzanne George, Margaret Von Mehren, Jonathan A Fletcher, Jichao Sun, Sen Zhang, Justin Pritchard, John G Hodgson, David Kerstein, Victor M Rivera, Frank G Haluska and Michael C Heinrich, 2022, "PHASE 2 STUDY OF PONATINIB IN ADVANCED GASTROINTESTINAL STROMAL TUMORS: EFFICACY, SAFETY, AND IMPACT OF LIQUID BIOPSY AND OTHER BIOMARKERS", Clinical Cancer Research
- Nathan B Wilke, Thu Nguyen-Anh Tran, Bethany Gentilesco, Scott M Leighow*, Emmy Albert, Emily R Strong, Karel Brinda, Haider Inam*, Fuhan Yang, Sajid Houssain*, Phillip Chan, William P Hanage, Maria Messick, Justin R Pritchard, Ephraim M Hanks and Maciej J Boni, 2022, "SARS-CoV-2 epidemic after social and economic reopening in three US states reveals shifts in age structure and clinical characteristics", Science Advances, 8, (4), pp. eabf9868
- Mickael Marloye, Haider Inam*, Connor J Moore*, Tyler R Mertens, Aude Ingels, Marlin Koch, Michal O Nowicki, Veronique Mathieu, Justin Pritchard, Samuel G Awuah, Sean E Lawler, Franck Meyer, Francois Dufrasne and Giles Berger, 2022, "Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity", Inorganic Chemistry Frontiers, (11)
- Karthik Hullahalli, Justin Pritchard and Matthew Waldor, 2021, "Refined quantification of infection bottlenecks and pathogen dissemination with STAMPR", mSystems, 6, (4)
- Thu Nguyen-Anh Tran, Nathan B Wilke, Emmy Albert, Haider Inam*, Emily Strong, Karel Brinda, Scott M Leighow*, Fuhan Yang, Sajid Hossain*, Justin Pritchard, Phillip Chan, William P Hanage and Maciej Boni, 2021, "Optimal SARS-CoV2 vaccine allocation using real-time attack-rate estimates in Rhode Island and Massachusetts", BMC Medicine, 19, (1), pp. 14
- Mickael Marloye, Haider Inam*, Connor Moore*, Vinciane Debaille, Justin Pritchard, Michel Gelbcke, Franck Meyer, Francois Dufrasne and Giles Berger, 2021, "Synthesis, structure and anticancer properties of new biotin and morpholine-functionalized ruthenium and osmium half-sandwich complexes", Journal of Biological Inorganic Chemistry, 26, pp. 14
- Nicholas Short, Hagop Kantarjian, Rashmi Shamanna, Koji Sasaki, Farhad Ravandi, Jorge Cortes, Marina Konopleva, Ghayas Issa, Steven Kornblau, Guillermo Manero, Rebecca Garris, Jake Higgins, Gabriel Pratt, Lindsey Williams, Charles Valentine, Victor Rivera, Justin Pritchard, Jesse Salk, Jerald Radich and Elias Jabbour, 2020, "Ultra-accurate Duplex Sequencing for the assesment of pretreatment ABL1 kinase domain mutations in Ph+ALL", Blood Cancer Journal, 10, (5), pp. 8
- Scott M Leighow*, Chuan Liu*, Haider Inam*, Boyang Zhao* and Justin Robert Pritchard, 2020, "Multi-scale predictions of drug resistance epidemiology identify design principles for rational drug design", Cell Reports, 30, pp. 12
- Peter M Bruno, Mengrou Lu*, Kady Dennis*, Haider Inam*, Connor Moore*, John Shehee*, Michael Hemann, Steven J Elledge and Justin Pritchard, 2020, "The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning", Proceedings of the National Academy of Sciences, 117, (8), pp. 7
- Boyang Zhao* and Justin Robert Pritchard, 2019, "Evolution of the nonsense-mediated decay (NMD) pathway is associated with decreased cytolytic immune infiltration", PLOS Computational Biology, (1)
- Laura Laencina, Violaine Dubois, Vincent Le Moigne, Albertus Viljoen, Laleh Majlessi, Justin Pritchard, Audrey Bernut, Laura Piel, Anne-Laure Roux, Jean-Louis Gaillard, Jean-Lois Herrmann and Fabienne Girard-Misguich, 2018, "Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus", Proceedings of the National Academy of Sciences, pp. 201713195
- Joseph M Gozgit, Tzu-Hsiu Chen, Youngchul Song, Scott Wardwell, Frank Wang, Jie Cai, Henry Li, Henrik Edgren, Victor M Rivera and Justin Pritchard, 2018, "RET fusions observed in lung and colorectal cancers are sensitive to ponatinib", Oncotarget, 9, (51), pp. 29654
- Michael W Schmitt, Justin Pritchard, Scott M Leighow*, Bella I Aminov, Lan Beppu, Daniel S Kim, J Graeme Hodgson, Victor M Rivera, Lawrence A Loeb and Jerald P Radich, 2018, "Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive Leukemias", Clinical Cancer Research, 24, (21), pp. 5321--5334
- Peter M Bruno, Yunpeng Liu, Ga Young Park, Yunko Murai, Catherine Koch, Timothy J Eisen, Justin Pritchard, Yves Pommier, Stephen J Lippard and Michael Hemann, 2017, "A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress", Nature Medicine, 23, pp. 461-471
- Jeremy Rock, Forest Hopkins, A Chavez, M Diallo, MR Chase, Elias Merrick, Justin Pritchard, Eric Rubin, George Church and Sarah Fortune, 2017, "Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform.", Nature Microbiology, 2, (4), pp. 16274
- Boyang Zhao and Justin Pritchard, 2016, "Inherited Disease Genetics Improves the Identification of Cancer-Associated Genes", Plos Genetics, 12, (6), pp. e1006081
- Boyang Zhao, Joseph C Sedlak, Raja Srinivas, Pau Creixell, Justin Pritchard, Bruce Tidor, Douglas A Lauffenburger and Michael T Hemann, 2016, "Exploiting temporal collateral sensitivity in tumor clonal evolution", Cell, 165, (1), pp. 234--246
- Theresa Baker, Sujata Nerle, Justin Pritchard, Boyang Zhao, Victor M Rivera, Andrew Garner and Francois Gonzalvez, 2015, "Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors", Oncotarget, 6, (32), pp. 32646
- Corbin E Meacham, Lee N Lawton, Yadira M Soto-Feliciano, Justin Pritchard, Brian A Joughin, Tobias Ehrenberger, Nina Fenouille, Johannes Zuber, Richard T Williams, Richard A Young and others, 2015, "A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth", Genes & development, 29, (5), pp. 483–488
- Joyce Wang, Justin Pritchard, Louis Kreitmann, Alexandre Montpetit and Marcel A Behr, 2014, "Disruption of Mycobacterium avium subsp. paratuberculosis-specific genes impairs in vivo fitness", BMC genomics, 15, (1), pp. 415
- Justin Pritchard, Michael C Chao, Sören Abel, Brigid M Davis, Catherine Baranowski, Yanjia J Zhang, Eric J Rubin and Matthew K Waldor, 2014, "ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing", PLoS genetics, 10, (11), pp. e1004782
- Boyang Zhao, Justin Pritchard, Douglas A Lauffenburger and Michael T Hemann, 2014, "Addressing genetic tumor heterogeneity through computationally predictive combination therapy", Cancer discovery, 4, (2), pp. 166--174
- Justin Pritchard, Peter M Bruno, Luke A Gilbert, Kelsey L Capron, Douglas A Lauffenburger and Michael T Hemann, 2013, "Defining principles of combination drug mechanisms of action", Proceedings of the National Academy of Sciences, 110, (2), pp. E170--E179
- Michael C Chao, Justin Pritchard, Yanjia J Zhang, Eric J Rubin, Jonathan Livny, Brigid M Davis and Matthew K Waldor, 2013, "High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model–based analyses of transposon-insertion sequencing data", Nucleic acids research, 41, (19), pp. 9033–9048
- Justin Pritchard, Peter M Bruno, Michael T Hemann and Douglas A Lauffenburger, 2013, "Predicting cancer drug mechanisms of action using molecular network signatures", Molecular BioSystems, 9, (7), pp. 1604–1619
- Justin Pritchard, 2012, "Understanding resistance to combination chemotherapy", Drug Resistance Updates, 15, (5), pp. 249-257
- Justin Pritchard, 2011, "BCL-2 family genetic profiling reveals microenvironment-specific determinants of therapeutic response.", Cancer Research, 71, (17), pp. 1014-1022
- Hai Jiang, Justin Pritchard, Richard T Williams, Douglas A Lauffenburger and Michael T Hemann, 2011, "A mammalian functional-genetic approach to characterizing cancer therapeutics", Nature chemical biology, 7, (2), pp. 92–100
- Justin Pritchard, Benjamin D Cosgrove, Michael T Hemann, Linda G Griffith, Jack R Wands and Douglas A Lauffenburger, 2009, "Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death", Molecular cancer therapeutics, 8, (8), pp. 2183–2192
- Benjamin D Cosgrove, Connie Cheng, Justin Pritchard, Donna B Stolz, Douglas A Lauffenburger and Linda G Griffith, 2008, "An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-$\alpha$", Hepatology, 48, (1), pp. 276--288
- Scott Leighow* and Justin Pritchard, , "The risks of perpetuating an evolutionary arms race in drug discovery", Evolution, Medicine, and Public Health
- Catriona Dowling, Kate Hollinshead, Alessandra Di Grande, Justin Pritchard, Hua Zhang, Eugene Dillon, Kathryn Haley, Eleni Papadopoulos, Anita Mehta, Rachel Bleach, Andreas Lindner, Brian Mooney, Heiko Dussman, Darran oconnor, Jochen Prehn, Kieran Wynne, Michael Hemann, James Bradner, Alec Kimmelman, Jennifer Guerriero, Gerard Cagney, Kwok-Kin Wong, Anthony Letai and Triona Ni Chonghaile, , "Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple negative breast cancer", Science Advances, 7, (3), pp. online
- Haider Inam*, Ivan Sokirniy*, Yiyun Rao*, Anushka Shah*, Farnaz Naeemikia*, Edward O'Brien, Cheng Dong and Justin Pritchard, , "Genomic and experimental evidence that alternate transcription initiation of the Anaplastic Lymphoma Kinase (ALK) kinase domain does not predict single agent sensitivity to", iScience, 24, pp. 21
- Yogodzinski Chris, Abolfazl Arab, Justin Pritchard, Hani Goodarzi and Luke Gilbert, , "A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy", Genome Medicine, 13, (1)
Abstracts
- Victor Rivera, Wei-Sheng Huang, Mengrou Lu, Justin Pritchard, David Dalgarno and William Shakespeare, 2021, "Preclinical characterization of THE-630, a next-generation inhibitor for KIT-mutant gastrointestinal stromal tumors (GIST)", Cancer Research, 81, (13), pp. 1
- Justin Pritchard, Michael W Schmitt, J Graeme Hodgson, Stephanie Lustgarten, Shijie Tang, Lawrence A Loeb, Jerald P Radich and Victor M Rivera, 2016, "Analysis of the Sub-Clonal Origins of Compound Mutations in Patients with Refractory Ph+ Malignancies Treated with Ponatinib", Blood
- Michael W Schmitt, Jesse J Salk, Edward J Fox, Justin Pritchard, J Graeme Hodgson, Victor M Rivera, Pamela S Becker, Jerald P Radich and Lawrence A Loeb, 2016, "Direct assessment of sequence heterogeneity in human cancers by Duplex Sequencing"
- Victor M Rivera, Susan Branford, Franck E Nicolini, Justin Pritchard, Joseph M Gozgit, Wolfgang Kern, Dragana Milojkovic, Simone Claudiani, Martin C Muller, Srinivas K Tantravahi and others, 2015, "A Multi-Institutional Retrospective Analysis of Tyrosine Kinase Inhibitor (TKI) Clinical and Preclinical Efficacy According to BCR-ABL Mutation Status in CP-CML Patients"
- Peter M Bruno, Ga Young Park, Junko Murai, Yunpeng Liu, Justin Pritchard, Yves Pommier, Stephen J Lippard and Michael T Hemann, 2015, "Abstract C56: Platinum containing anti-cancer agents as targeted therapeutics"
- Justin Pritchard, Stephanie Lustgarten, Graeme Hodgson, Michele Baccarani, Jorge E Cortes, Michael W Deininger, Francois Guilhot, Andreas Hochhaus, Timothy P Hughes, Neil P Shah and others, 2015, "High-Resolution Analysis of the Relationship Between Ponatinib Dose and Molecular Response in CP-CML Patients in the PACE Trial", Clinical Lymphoma, Myeloma and Leukemia, 15, pp. S212
- Victor M Rivera, Susan Branford, Franck E Nicolini, Justin Pritchard, Joseph M Gozgit, Wolfgang Kern, Dragana Milojkovic, Simone Claudiani, Martin C Muller, Srinivas K Tantravahi and others, 2015, "A Multi-Institutional Retrospective Analysis of Tyrosine Kinase Inhibitor (TKI) Clinical and Preclinical Efficacy According to BCR-ABL Mutation Status in CP-CML Patients"
- Michael W Schmitt, Justin Pritchard, Graeme Hodgson, Victor M Rivera, Bella I Aminov, Lan Beppu, Lawrence A Loeb and Jerald P Radich, 2015, "Emergence of sub-clonal drug resistance mutations during CML therapy"
- Justin Pritchard, S Lustgarten, JG Hodgson, M Baccarani, JE Cortes, MW Deininger, F Guilhot, TP Hughes, NP Shah, M Talpaz and others, 2015, "Analysis of the relationship between dose and BCR-ABL halving time in CP-CML patients treated with ponatinib or imatinib", 100, pp. 448–449
- Michael C Heinrich, J Graeme Hodgson, Margaret von Mehren, George D Demetri, Jonathan A Fletcher, Jichao G Sun, Justin Pritchard, Sen Zhang, Victor M Rivera and Suzanne George, 2015, "Detection of KIT mutants in circulating tumor DNA (ctDNA) and their association with ponatinib anti-tumor activity in patients (pts) with advanced gastrointestinal stromal tumors (GIST)."
- Justin Pritchard, Stephanie Lustgarten, Graeme Hodgson, Michele Baccarani, Jorge E Cortes, Michael W Deininger, Francois Guilhot, Andreas Hochhaus, Timothy P Hughes, Neil P Shah and others, 2015, "High-Resolution Analysis of the Relationship Between Ponatinib Dose and Molecular Response in CP-CML Patients in the PACE Trial", Clinical Lymphoma, Myeloma and Leukemia, 15, pp. S212
- Victor M Rivera, Justin Pritchard, Francois Gonzalvez, Theresa Baker, Joseph M Gozgit and Graeme Hodgson, 2014, "Comparative TKI profiling analyses to explore potential mechanisms of ponatinib-associated arterial thrombotic events"
- Justin Pritchard, Stephanie Lustgarten, Graeme Hodgson, Michele Baccarani, Jorge E Cortes, Michael W Deininger, Francois Guilhot, Andreas Hochhaus, Timothy P Hughes, Neil P Shah and others, 2014, "High-resolution analysis of the relationship between dose and molecular response in CP-CML patients treated with ponatinib or imatinib"
Other
- Hai Jiang, Justin Pritchard, Douglas A Lauffenburger and Michael Hemann, 2017, "RNAi-based method of drug screening and characterization"
- Justin Pritchard, Douglas A Lauffenburger and Michael Hemann, 2017, "RNAi-based method of screening and characterizing drug combinations"
- Francois Gonzalvez, Theresa A Baker, Justin Pritchard, Victor M Rivera and Andrew Garner, 2015, "EZH2 D1 domain mutants confer acquired resistance to EZH2-targeted inhibitors and reprogram B-cell transcription"
- Douglas A Lauffenburger, Boyang Zhao, Justin Pritchard and Michael T Hemann, 2013, "Abstract IA10: Targeting intratumoral genetic heterogeneity through rationally designed combination therapy"
- Douglas A Lauffenburger, Justin Pritchard and Michael T Hemann, 2012, "Abstract SY22-02: Mammalian functional genetic signatures identify efficacy landscapes of combination chemotherapy"
